The 191st Infantry Brigade, was first formed as part of the United States Army Reserve's 96th Division.
Seemingly in 1941-42, the brigade headquarters was inactivated as part of conversion of the 96th Division from a two-brigade, four-regiment division to a three-regiment 'triangular' division. The brigade headquarters personnel and assets apparently forme d the core of the divisional headquarters company. Therefore, the headquarters of the 191st Infantry Brigade did not see any World War II service.
In December 2006, the 191st Brigade was activated using the personnel & assets of 4th Brigade, 91st Division (Training Support) and assumed the mission to train Army Reserve & National Guard units.
In September 2012, elements of the 191st Infantry Brigade HQ deployed as an SFAT team to eastern Afghanistan in support of Operation ENDURING FREEDOM.