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Description: What is endometriosis? Endometriosis is a painful disorder in which tissue that normally lines the inside of uterus grows outside it. Endometriosis can cause pain, sometimes severe, especially during period. Fertility problems may develop. Endometriosis affects 1 in 10 women worldwide. Due to the lack of research the exact cause of endometriosis is not certain and there are no known ways to prevent its development.